Ensiklopedia

HGF
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	1BHT , 1GMN , 1GMO , 1GP9 , 1NK1 , 1SHY , 1SI5 , 2HGF , 2QJ2 , 3HMS , 3HMT , 3HN4 , 3MKP , 3SP8 , 4K3J , 4O3T , 4O3U , 5COE , 5CP9 , 5CS1 , 5CS3 , 5CS5 , 5CS9 , 5CSQ , 5CT1 , 5CT2 , 5CT3 , 4D3C
Pengidentifikasi
	HGF , DFNB39, F-TCF, HGFB, HPTA, SF, hepatocyte growth factor
ID eksternal	142409 96079 503 HGF
Lokasi gen (Tikus)
Kr.	Kromosom 5 (tikus)
Akhir	16,825,150 bp
Pola ekspresi RNA
	; ; ; ;
	Referensi data ekspresi selengkapnya
Fungsi molekuler	• GO:0001948, GO:0016582 Ikatan protein plasma ; • pengikatan protein identik ; • chemoattractant activity ; • protein heterodimerization activity ; • growth factor activity ; • serine-type endopeptidase activity ; • protein tyrosine kinase activity ; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity ;
Komponen seluler	• membran ; • extracellular region ; • platelet alpha granule lumen ; • extracellular space ;
Proses biologis	• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ; • negative regulation of hydrogen peroxide-mediated programmed cell death ; • positive regulation of neuron projection regeneration ; • positive regulation of interleukin-10 production ; • positive regulation of cell migration ; • cellular response to hepatocyte growth factor stimulus ; • negative regulation of release of cytochrome c from mitochondria ; • negative regulation of interleukin-6 production ; • platelet degranulation ; • negative regulation of apoptotic process ; • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling ; • positive regulation of angiogenesis ; • positive regulation of myelination ; • positive regulation of osteoblast differentiation ; • myoblast proliferation ; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ; • animal organ regeneration ; • GO:0000767 cell morphogenesis ; • positive regulation of cell population proliferation ; • hyaluronan metabolic process ; • positive regulation of DNA biosynthetic process ; • negative regulation of peptidyl-serine phosphorylation ; • Transisi epitelial-mesenkimal ; • positive regulation of peptidyl-tyrosine phosphorylation ; • cell chemotaxis ; • liver development ; • positive regulation of phosphatidylinositol 3-kinase signaling ; • regulation of p38MAPK cascade ; • cell population proliferation ; • negative regulation of autophagy ; • hepatocyte growth factor receptor signaling pathway ; • negative regulation of inflammatory response ; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II ; • regulation of tau-protein kinase activity ; • Proteolisis ; • positive chemotaxis ; • MAPK cascade ; • peptidyl-tyrosine phosphorylation ; • phosphatidylinositol phosphate biosynthetic process ; • GO:0007067 mitosis ; • regulation of signaling receptor activity ; • positive regulation of protein kinase B signaling ; • positive regulation of protein phosphorylation ; • cytokine-mediated signaling pathway ; • epithelial cell proliferation ;
	Sumber: Amigo / QuickGO
	3082
	15234
	ENSG00000019991
	ENSMUSG00000028864
	P14210
	Q08048
	NM_000601 ; NM_001010931 ; NM_001010932 ; NM_001010933 ; NM_001010934
	NM_010427 ; NM_001289458 ; NM_001289459 ; NM_001289460 ; NM_001289461
	NP_000592 ; NP_001010931 ; NP_001010932 ; NP_001010933 ; NP_001010934
	NP_001276387 ; NP_001276388 ; NP_001276389 ; NP_001276390 ; NP_034557
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Faktor pertumbuhan hepatosit ( bahasa Inggris : hepatocyte growth factor, scatter factor, hepapoietin A, SF, HGFB, HPTA, F-TCF, DFNB39, HGF ) adalah sitokina hasil sekresi yang memiliki multi-fungsi antara lain berperan dalam perkembangan sel , motilitas , morfogenesis pada lintasan tirosina kinase , sehingga mempunyai peran penting dalam angiogenesis , dan perbaikan jaringan tubuh . ^{[

4

]}

HGF disekresi sebagai polipeptida yang tidak aktif dan kemudian teriris oleh menjadi rantai alfa dengan massa 69 kDa dan rantai beta dengan massa 34 kDa.

Rendahnya rasio HGF di dalam plasma darah dianggap merupakan pemicu terjadinya hepatitis kronis, karena pengaruh HGF yang bersifat anti- apoptotik , anti- radang terhadap hepatosit . ^{[

5

]} ^{[

6

]} Rasio HGF yang rendah, dapat ditingkatkan oleh induksi asam maleat , ^{[

7

]} atau dengan asupan buah Momordica charantia L. secara teratur. ^{[

8

]} Sekresi HGF juga dapat diinduksi oleh aktivasi dan , EGF , TNF-α , ^{[

9

]} dan interferon-gamma . Efek yang diberikan oleh interferon-gamma, tidak dapat disubstitusi oleh interferon-alfa maupun interferon-beta. ^{[

10

]}

Rujukan

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028864 - , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ (Inggris) "HGF hepatocyte growth factor (hepapoietin A; scatter factor) [ Homo sapiens ]" . Entrez Gene . Diarsipkan dari versi asli tanggal 2023-07-17 . Diakses tanggal 2010-07-28 .
^ (Inggris) "Hepatocyte growth factor: a regenerative drug for acute hepatitis and liver cirrhosis" . Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine; Mizuno S, Nakamura T . Diarsipkan dari versi asli tanggal 2009-05-11 . Diakses tanggal 2010-07-28 .
^ (Inggris) "Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis" . Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine; Kim WH, Matsumoto K, Bessho K, Nakamura T . Diarsipkan dari versi asli tanggal 2008-12-01 . Diakses tanggal 2010-07-28 .
^ (Inggris) "Induction of hepatocyte growth factor expression by maleic acid in human fibroblasts through MAPK activation" . Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Motoki T, Sugiura Y, Matsumoto Y, Tsuji T, Kubota S, Takigawa M, Gohda E . Diarsipkan dari versi asli tanggal 2023-07-17 . Diakses tanggal 2010-07-28 .
^ (Inggris) "Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp" . Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Ono T, Tsuji T, Sakai M, Yukizaki C, Ino H, Akagi I, Hiramatsu K, Matsumoto Y, Sugiura Y, Uto H, Tsubouchi H, Gohda E . Diarsipkan dari versi asli tanggal 2023-07-17 . Diakses tanggal 2010-07-28 .
^ (Inggris) "Inhibition of hepatocyte growth factor induction in human dermal fibroblasts by interleukin-1 and its prevention by interferon-gamma" . Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University; Takami Y, Kanasaki K, Tsubouchi H, Ishii T, Yamamoto I, Gohda E . Diarsipkan dari versi asli tanggal 2023-07-17 . Diakses tanggal 2010-07-28 .
^ (Inggris) "Synergistic induction of hepatocyte growth factor in human skin fibroblasts by the inflammatory cytokines interleukin-1 and interferon-gamma" . Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University; Takami Y, Motoki T, Yamamoto I, Gohda E . Diarsipkan dari versi asli tanggal 2023-07-17 . Diakses tanggal 2010-07-28 .

Artikel bertopik biokimia ini adalah sebuah rintisan . Anda dapat membantu Wikipedia dengan .

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000028864 - , May 2017

[2] "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[3] "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .

[4] (Inggris) "HGF hepatocyte growth factor (hepapoietin A; scatter factor) [ Homo sapiens ]" . Entrez Gene . Diarsipkan dari versi asli tanggal 2023-07-17 . Diakses tanggal 2010-07-28 .

[5] (Inggris) "Hepatocyte growth factor: a regenerative drug for acute hepatitis and liver cirrhosis" . Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine; Mizuno S, Nakamura T . Diarsipkan dari versi asli tanggal 2009-05-11 . Diakses tanggal 2010-07-28 .

[6] (Inggris) "Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis" . Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine; Kim WH, Matsumoto K, Bessho K, Nakamura T . Diarsipkan dari versi asli tanggal 2008-12-01 . Diakses tanggal 2010-07-28 .

[7] (Inggris) "Induction of hepatocyte growth factor expression by maleic acid in human fibroblasts through MAPK activation" . Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Motoki T, Sugiura Y, Matsumoto Y, Tsuji T, Kubota S, Takigawa M, Gohda E . Diarsipkan dari versi asli tanggal 2023-07-17 . Diakses tanggal 2010-07-28 .

[8] (Inggris) "Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp" . Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Ono T, Tsuji T, Sakai M, Yukizaki C, Ino H, Akagi I, Hiramatsu K, Matsumoto Y, Sugiura Y, Uto H, Tsubouchi H, Gohda E . Diarsipkan dari versi asli tanggal 2023-07-17 . Diakses tanggal 2010-07-28 .

[9] (Inggris) "Inhibition of hepatocyte growth factor induction in human dermal fibroblasts by interleukin-1 and its prevention by interferon-gamma" . Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University; Takami Y, Kanasaki K, Tsubouchi H, Ishii T, Yamamoto I, Gohda E . Diarsipkan dari versi asli tanggal 2023-07-17 . Diakses tanggal 2010-07-28 .

[10] (Inggris) "Synergistic induction of hepatocyte growth factor in human skin fibroblasts by the inflammatory cytokines interleukin-1 and interferon-gamma" . Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University; Takami Y, Motoki T, Yamamoto I, Gohda E . Diarsipkan dari versi asli tanggal 2023-07-17 . Diakses tanggal 2010-07-28 .

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Ensiklopedia

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