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"If you look at the history of breakthroughs in disease, often the understanding of what proteins normally do gives important clues to what is aberrant in disease" - Lawrence S. B. Goldstein; Howard Hughes Institute

"Disconcertingly few laymen-even few college graduates-really understand what the scholar means by 'truth.' It is not a citadel of certainty to be defended against error; it is a shady spot where one eats lunch before tramping on. The professional thinker enjoys being where he is, but he also looks forward to new vistas around the next bend, over the next crest." - Lynn White, Machina ex Deo; Massachusetts Institute of Technology

"Of course, I might have been wrong, and in any case, was it not the great Max Planck (1928, 1933) who remarked that a new scientific idea does not triumph by convincing its opponents, but rather because its opponents eventually die?" - Peter Mitchell, Chemiosmotic Theory; Glynn Research Institute

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"A vitamin is a substance that makes you ill if you don’t eat it." - Albert Szent-Gyorgyi, Nobel Prize in Physiology or Medicine, 1937

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• Atherosclerosis and NIDDM share the same pathogenesis of β-oxidation deficiency.
• BMR is a ratio of each respective speed,

${\displaystyle d2{\mbox{ATP}}\leftarrow 2{\mbox{(ADP + Pi)}} \over d2{\mbox{H}}_{2}{\mbox{O}}\leftarrow {\mbox{O}}_{2}+4{\mbox{H}}^{+}+4{\mbox{e}}^{-}\,}$ or ${\displaystyle {\mbox{ATP Biosynthesis}} \over {\mbox{Deprotonation}}\,}$

• Phosphatidylcholine collapses into cytoplasm in state of acidic matrix.
• Hyperthyroidism and hypothyroidism share the same mitochondrial complex I deficiency.
• If product of deiodination, oxidative phosphorylation and Krebs' cycle were Lorentz force , excessive force over the threshold will be coupled by an anti-Lorents force generated by a mechanism called chemiosmotic coupling.
• Ion H ⁺ from mitochondrial deprotonation is used at least for replacing damaged DNA double helix hidrogen bond inside nucleus .
• Over- transcription without sufficient deprotonation results to over-expression of complement protein .
• Thiamine is a carrier in cytoplasm that transports oxygen into mitochondrial matrix for oxidative phosphorylation .
• Although hypothyroidism might share the same metabolic pathways with hypothyroxinaemia, hyperthyroxinaemia does not do the same with hyperthyroidism , because it primarily deals with excessive deprotonation which disrupts glutamate cycle and shifts partitions in biological water zone and accidentally inhibits carrier activities which transports oxygen into mitochondrial matrix, and thus results to metabolic storm.
• Enzymatic activities in biological water zone in cytoplasm which is capable of maintaining the mode of deprotonation to partition equilibrium, defines the state of addiction.
• Mitochondrion is a prokaryote cell evolved from α-proteobacteria which used to live in apple , having with human eukaryote . Endosymbiosis with one living in banana is what makes monkey .
• At each locus, human posseses two alleles , one inherited from the father and one from the mother. Each time a genetic mutation takes place, human get a new additional allele, because every parenthood affair causes a genetic mutation in their children as side effect of inheritance.
• ATPases from both eukaryote and prokaryote are the same in case of mitochondrion endosymbiotic evolution . As the result, oxidative phosphorylation also occurs at plasma membrane , Krebs' cycle also takes place in cytoplasm . Thus references which describe plasmalemma ATPase can be used to describe properties of mitochondrion ATPase. After all, they have the same molecular structure.
• Human can stay young upon maintaining plasma deiodination rate.
• In organic chemistry , there are gears of redoks that tick and tock like those of the clocks. Biological water zone distributes the power of ion H ⁺ from mitochondrial to drive all gears in certain partitions. Ticks and tocks generate heat from their friction , so in order to avoid overheating by adjacent gear subtrates which may catalyze the friction like an enzyme , a regulation of a promoter compound is in order. By the way, there is a second substrate type, like paper for the gears of and, for those orphan gears, there are universal gears called ATP placed in adjacent.
• Scientific methodology is about good business. For example, a gentleman doing a research with a phenomenal result that exceeds the current phylosophy, after that, he got banned and considered a rebel by his own community. In this case, scientific methodology offers a win-win solution, this gentleman can forget about the hardwork and all his scientific methods and perspiration, as all those will be considered as development and progress of old concept that once banned him, in return, he can have the title as Father of Modern Chemistry.
• Vitamin C together with Vitamin B1 can be anti- cancer supplement. Vitamin C with Matrix Metalloproteinases , and Vitamin B1 with HIF.
• Faster heartbeat is one genetic expression of GLO from functional chromosome 8p21.1.
• Chain of command does not begin with vandalism.
• In photography , a world next door to automobile which begins with gears, cancer is not just carcinogen -induced synergetic somatic mutations, but it happens in absentia of spesific determining gears. High BMR in cancer also is not simply because of Warburg effect , which in BMR equation shown by increase of ATP biosynthesis rate, but also because of decrease in deprotonation rate. Based on this gear point of view, cancer can be seen as a form of , because, partition obstacles of cytoplasmic biological water zone might prevent mitochondrial deprotonation product to reach periplasm and deprotonation-like function is substituted by Bohric erythrocyte in blood vessels , and by vitamin in various tissues . People are people, prefer to reduce ATP by fasting to increasing ion H ⁺ by consuming vitamins, because of fear that gears might burn while rotating too fast.
• Biological water zone is not applicable for lung cells , because of incident free air .
• Master degree scholars who still like to translate words to words tightly according to lexical grammatical rules and inherit all the mistakes done in last summary, do not need higher education to understand the copyvio nature of their translations.
• In nature , statics is divided into 2 major layers, the air and water . The soil creates sublayers that due to their molecule weights , and oil on top of it. In dynamics, pulsatic heartbeat not only drive oily particles faster, but it bends the entire statics into complete circle and builds many concentric layers. Its longitudinal creates centrifugal force which drive heavier particles outwards. Thus because of difference in transversal speed, small molecule oxidants will not likely oxidize larger molecules in outer different layer, and the oxidized molecules will likely to fall outward into water layer, attracted by deprotonation from whatever cells or parenchymes nearby. But sometimes, as people do some sports, the transversal pulses create centripetal force and brings up singularity effect, where small and large molecules mixed up together. From this, it can be determined that triglyceride holds an important homeostasis between and cancer as its particular oxidizing partner, CEA .
• We were all stupid once.
• Cells which undergo thiamine deficiency and fail becoming cancerous through Warburg pathway, will die to edema . Body may suffer from albuminuria as it activates detoxification pathway to clear out excessive fluid from within peritoneum .
• C is black , O ₂ is blue , but CO ₂ is not dark blue. It's green .
• Body circadian rhytm is in vicinity of 3 bases of liver mode. First base is protein base when liver secretes albumin , second one is lipid base when liver secretes products from beta- oxydation , third base is water base when liver induces glucuronidation pathway.
• People who see heart as an organ which pumps blood into artery will think of it as a mechanism which creates . Others who see heart as an organ which sucks blood from vein , will think of albumin to meet systolic pressure .
• Noone can satisfy everyone.

• Father, Son, Holy Spirit
• Father, Mother, Children
• Read, Learn, Edit
• Acid, Base, Salt
• Innate, Adaptive, Complement
• Nerve system, Metabolic system, Immune system
• Protein, Fat, Glucose
• Tri-iodothyronine, Melatonin, Insulin
• Tumor necrosis factor-α, Hepatocyte growth factor, Interferon-γ
• Neutron, Proton, Electron
• Cardiolipin, Phosphatidylcholine, Phosphatidylethanolamine
• Deiodination, Krebs cycle, Oxidative Phosphorylation
• Triglyceride, Uric Acid, Urea

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